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KMID : 0931320120120020088
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대한상부위장관.헬리코박터학회지
2012 Volume.12 No. 2 p.88 ~ p.95
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Meta-analysis: the Effect of Lactobacillus Supplementation on Helicobacter pylori Eradication Rates and Side Effects during Treatment
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Choi Ju-Young
Shim Ki-Nam
kwon Kyoung-Joo
Song Eun-Mi
Kim Seong-Eun
Jung Hye-Kyung
Jung Sung-Ae
Kong Kyoung-Ae
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Abstract
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Background/Aims: Helicobacter pylori (H. pylori) is causally associated with gastritis and peptic ulcer diseases. Recent data have demonstrated that triple therapy with amoxicillin, clarithromycin, and a proton pump inhibitor has an eradication rate of only 74∼76% and new therapeutic protocols may be necessary. The aim of this study was to investigate the effects of Lactobacillus as supplementation to anti-H. pylori regimens on H. pylori eradication rates and therapy-associated side effects.
Materials and Methods: The PubMed, Medline and Korean Medical Database were searched in January 2012, with no language restrictions, for randomized controlled trials; additional references were obtained from reviewed articles. We included trials comparing Lactobacillus supplementation to placebo or no treatment during anti-H. pylori regimens. Meta-analysis was performed with Review Manager.
Results: Eleven trials involving a total of 1,107 participants met the inclusion criteria. Compared with placebo or no intervention, Lactobacillus given along with anti-H. pylori regimens significantly increased the eradication rate [84.7% vs. 78.8%, odds ratio (OR) 1.75, 95% confidence interval (CI) 1.26∼2.42] and reduced the risk of overall H. pylori therapy related adverse effects (35.4% vs. 48.6%, OR 0.56, 95% CI 0.38∼0.81), particularly of diarrhea (7.5% vs. 20.6%, OR 0.31, 95% CI 0.18∼0.54), bloating (19.2% vs. 29.9%, OR 0.53, 95% CI 0.32∼0.88) and taste disturbance (17.6% vs. 34.8%, OR 0.37, 95% CI 0.21∼0.64). There were no significant differences between groups in the risk of other adverse effects.
Conclusions: Our review suggests that supplementation with Lactobacilli could be effective in increasing eradication rates of anti-H. pylori therapy. Furthermore, Lactobacilli showed a positive impact on some H. pylori therapy-related side effects, particularly diarrhea, bloating and taste disturbance.
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KEYWORD
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Helicobacter pylori, Lactobacillus, Eradication, Side effects
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